Isolated limb infusion (ILI) with anti-cancer drugs is a form of treatment which may be offered to patients with recurrent melanoma or other types of tumour confined to a limb.
A technique which is very similar in principle but technically much more complex, known as isolated limb perfusion (ILP) was developed in the early 1960’s by surgeons in New Orleans, based on early heart/lung bypass technology.
In the early 1990’s the alternative technique of ILI was developed in Sydney, Australia. ILI is much less complex and requires no surgical incision, yet appears to be just as effective as conventional ILP. Additional benefits of ILI are that it can easily be repeated if necessary, it does not require routine blood transfusion, and it can sometimes be performed in patients who would not be considered medically suitable for ILP.